README for Supplemental Code File 1

This folder contains the custom Python script dir_searcher.py, which was used for downstream analysis of NetTracer3D-derived CSV outputs, including similarity quantification and overlaid histogram generation.

The script searches CSV files within the het/ and homo/ directories, combines data across samples, calculates distribution similarity using Jensen-Shannon distance, performs statistical comparisons, and generates summary CSV files and histogram plots.

The script requires Python with pandas, numpy, matplotlib, and scipy.

NetTracer3D is open source and publicly available at https://pypi.org/project/nettracer3d/.
